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We show that respiratory fluoroquinolone use is extremely seasonal and that fluoroquinolone use is strongly associated with influenza. In our time series model, instantaneous influenza activity was a significant predictor of use ([Formula: see text]). Also, we estimated that reducing influenza activity by 20% would reduce prescriptions by 8%.

Philip M. Polgreen
M. Yang
Ramanan Laxminarayan
J. E. Cavanaugh